The Inter-American Drug Abuse Control Commission (CICAD), a consultative and advisory body to the OAS, serves as a forum for addressing the drug problem. It provides technical assistance for capacity building and, since 1986, has promoted regional cooperation to address the evolving challenges of drug control.

The Department against Transnational Organized Crime (DTOC), provides technical and legislative assistance to OAS Member States to combat organized crime. Established in 2016, It promotes regional cooperation projects, assesses and prevents various forms of transnational crime, and offers Technical Secretariat services to specialized forums in the field.

The Executive Secretariat of the Inter-American Committee against Terrorism (CICTE) supports Member States in their efforts to prevent and counter terrorism through programs on topics such as cybersecurity, border controls, prevention of the proliferation of weapons of mass destruction and violent extremism

The Department of Public Security (DSP) supports the Member States in the assessment, prevention, diagnosis, and response to security threats in the Americas. DSP actions include providing technical assistance, contributing to the implementation of regulatory frameworks, and promoting international cooperation and horizontal exchange to strengthen public security in the region.